姓名：冯梅
职称：讲师
办公室：A4-302
邮箱：fengmei@zust.edu.cn
主要研究方向：计算生物物理、计算软凝聚态物理。用基于物理的方法（分子动力学模拟、自由能计算）结合机器学习来解决医学问题（肿瘤免疫中的新生抗原设计、抗体设计）并进行实验验证。
个人简介：博士，硕士生导师。2008年3月浙江大学物理学院博士毕业，2008.04-2020.03浙江大学物理学院博士后，2020.04-2025.03兰州大学物理学院青年研究员，2025.04-今浙江科技大学理学院。主持国家自然科学基金青年项目一项（2024-2026），主持中国博士后科学基金面上项目一项（2019-2020）。发表多篇SCI论文，包括JACS、Chemical Science等TOP期刊。
科研论文：
1. Mei Feng*, Nan Wang, Yan Wang, Bijun Xu, Xiaogang Wang, Tingting Sun*. Length-dependent Nanopore Transport and Surface-induced Unfolding of Polyglutamine Chains. Chinese Journal of Polymer Science, 2026, 44: 1-8.
2. Mei Feng#, Kevin C. Chan#, Qinglu Zhong, Ruhong Zhou*. In Silico Design of High-affinity Antigenic Peptides for HLA-B44. International Journal of Biological Macromolecules, 2024, 267(Pt 2): 31356.
3. Mei Feng#, Yi Song#, Ruhong Zhou*. Chapter 11: Calculation of Relative Binding Free Energy for Mutations in Protein Complexes: The Alchemical Path. In: A Practical Guide to Recent Advances in Multiscale Modeling and Simulation of Biomolecules. AIP Publishing Books, 2023: 1-18.
4. Mei Feng#, Yi Song#, Serena Chen, Yuanzhao Zhang, Ruhong Zhou*. Molecular Mechanism of Secreted Amyloid-β Precursor Protein in Binding and Modulating GABABR1a. Chemical Science, 2021, 12(17): 6107-6116.
5. Mei Feng#, Sangyun Lee#, Chun Chan, Ruhong Zhou*. Molecular Insight into AC Electric Field Enhanced Removal of Protein Aggregates from a Material Surface. Journal of Physical Chemistry B, 2021, 125(44): 12147–12153.
6. Mei Feng*, David Bell, Zhenhua Wang, Wei Zhang. Length-dependent Structural Transformations of Huntingtin PolyQ Domain Upon Binding to 2D Nanomaterials. Frontiers in Chemistry, 2020, 8: 299-306.
7. Mei Feng, David Bell, Hongsuk Kang, Qiwen Shao, Ruhong Zhou*. Exploration of HIV-1 Fusion Peptide-Antibody VRC34.01 Binding Reveals Fundamental Neutralization Sites. Physical Chemistry Chemical Physics, 2019, 21(34): 18569-18576.
8. Mei Feng, David Bell, Judong Luo, Ruhong Zhou*. Impact of Graphyne on Structural and Dynamical Properties of Calmodulin. Physical Chemistry Chemical Physics, 2017, 19(15): 10187-10195.
9. Mei Feng, David Bell, Ruhong Zhou*. Propensity of a Single-walled Carbon Nanotube-Peptide to Mimic a KK10 Peptide in an HLA-TCR Complex. Journal of Chemical Physics, 2017, 147(22): 225101.
10. Mei Feng, Hongsuk Kang, Zaixing Yang, Binquan Luan, Ruhong Zhou*. Potential Disruption of Protein-Protein Interactions by Graphene Oxide. Journal of Chemical Physics, 2016, 144(22): 225102.
11. Mei Feng, Xiaoyan Zhou, Jianlong Kou, Fengmin Wu, Chunlei Wang, Hangjun Lu*. A Transition between Bistable Ice When Coupling Electric Field and Nanoconfinement. Journal of Chemical Physics, 2015, 142(13): 134704.
12. Binquan Luan#, Guangxue Xu#, Mei Feng, Le Cong*, Ruhong Zhou*. Combined Computational-Experimental Approach to Explore Molecular Mechanism of SaCas9 with Broadened DNA Targeting Range. Journal of the American Chemical Society, 2019, 141(16): 6545-6552.
科研项目：
1. 国家自然科学基金委员会, 青年科学基金项目, 12302408, HLA-B44肿瘤新生抗原优化设计的计算模拟研究, 2024-01 至 2026-12, 30万元, 在研, 主持
2. 国家自然科学基金委员会, 面上项目, 11974305, 拥挤环境中链状大分子亚扩散的模拟研究, 2020-01 至 2023-12, 63万元, 结题, 第一参与人
3. 中国博士后科学基金委员会, 面上项目, 2019M652052, 二维纳米材料与蛋白质的界面 作用机制的研究, 2019-05至 2020-03, 8万元, 结题, 主持
教研项目：
浙江科技大学2025年度研究生课程建设项目，主持
